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Cell Cycle. 2006 Nov 1;5(21):2447-51. Epub 2006 Sep 12.

ZW10 function in mitotic checkpoint control, dynein targeting and membrane trafficking: is dynein the unifying theme?

Author information

1
Deptartment of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA. rv2025@columbia.edu

Abstract

ZW10 was initially identified as a mitotic checkpoint protein involved in chromosome segregation. It was subsequently implicated in targeting cytoplasmic dynein and dynactin to mitotic kinetochores, though the relationship between these functions remains incompletely understood. Recent studies have revealed that ZW10 performs important functions in nondividing cells as well. These include cytoplasmic dynein targeting to Golgi and other membranes, but also SNARE-mediated ER-Golgi trafficking. Identifying a unifying function for ZW10 in these diverse contexts has been elusive, but likely involves cytoplasmic dynein, as discussed here.

PMID:
17102640
PMCID:
PMC2794429
DOI:
10.4161/cc.5.21.3395
[Indexed for MEDLINE]
Free PMC Article

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