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Infect Immun. 2007 Jan;75(1):531-5. Epub 2006 Nov 13.

Different roles of the two high-oxygen-affinity terminal oxidases of Brucella suis: Cytochrome c oxidase, but not ubiquinol oxidase, is required for persistence in mice.

Author information

1
Institut National de la Santé et de la Recherche Médicale, U431, Montpellier, F-34095 France.

Abstract

The survival of Brucella suis mutant strains in mice demonstrated different roles of the two high-oxygen-affinity terminal oxidases. The cbb3-type cytochrome c oxidase was essential for chronic infection in oxygen-deficient organs. Lack of the cytochrome bd ubiquinol oxidase led to hypervirulence of bacteria, which could rely on nitrite accumulation inhibiting the inducible nitric oxide synthase of the host.

PMID:
17101669
PMCID:
PMC1828397
DOI:
10.1128/IAI.01185-06
[Indexed for MEDLINE]
Free PMC Article

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