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Infect Immun. 2007 Feb;75(2):1040-4. Epub 2006 Nov 13.

Surface proteins and exotoxins are required for the pathogenesis of Staphylococcus aureus pneumonia.

Author information

1
Department of Microbiology, University of Chicago, 920 E. 58th St., Chicago, IL 60637, USA.

Abstract

A model of Staphylococcus aureus-induced pneumonia in adult, immunocompetent C57BL/6J mice is described. This model closely mimics the clinical and pathological features of pneumonia in human patients. Using this system, we defined a role for S. aureus strain Newman surface proteins and secreted exotoxins in pneumonia-related mortality.

PMID:
17101657
PMCID:
PMC1828520
DOI:
10.1128/IAI.01313-06
[Indexed for MEDLINE]
Free PMC Article
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