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Lik Sprava. 2006 Apr-May;(3):61-5.

[Noliprel efficiency in patients with hypertension].

[Article in Ukrainian]


Monotherapy prevailing nowadays in the treatment of essential hypertension is one of the causes of not sufficiently effective hypotensive therapy. Combination of antihypertensive drugs is a more efficient strategy as synergism of applied medications may be reached and not high doses may develop less adverse effects. 30 patients (17 men and 13 women, average age is 51 years) with hypertension which have not taken antihypertensive drugs from different reasons have been prescribed Noliprel being a combination of Perindopril and Indapamid in low doses (2.00 mg and 0.625 mg accordingly) for 3 months. The study conducted by the author differs from the trials on Noliprel effectiveness by its more profound investigation of the echocardiography parameters and cardial hemodynamics. The measurement of left ventricular myocardium mass index, wall and interventricular septal thickness and many other echocardiographic parameters have been studied. Noliprel has already demonstrated good antihypertensive activity in 83.3% of patients after one month therapy. 16.7% of patient increased dose intake to two pills per day and after 3 months of the therapy their arterial pressure reached the target level. The author considered in details the dynamics of echocardiography parameters during therapy with Noliprel. Noliprel is a highly effective and safe medication which positively influences on processes of myocardium remodeling and is metabolically neutral. No side effects have been seen during the treatment with this medication by the patients having been treated.

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