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Curr Opin Pediatr. 2006 Dec;18(6):628-33.

Developmental factors regulating susceptibility to perinatal brain injury and seizures.

Author information

1
Department of Neurology, Children's Hospital, Program in Neurobiology, Harvard Medical School, Boston, MA 02114, USA. frances.jensen@childrens.harvard.edu

Abstract

PURPOSE OF REVIEW:

To review the unique pattern of developmentally regulated factors that govern the susceptibility of the brain during the preterm and term windows of development.

RECENT FINDINGS:

The neonatal brain shows unique regional differences in susceptibility to injury. In response to the common insult of hypoxia/ischemia, the preterm brain exhibits regional white matter susceptibility, while gray matter is affected in the term brain. Developmental regulation of specific cellular factors is likely to underlie these age-specific differences.

SUMMARY:

A better understanding of these factors could contribute to the development of new age-specific therapeutic strategies with clinical potential for disorders such as periventricular leukomalacia in the preterm and neonatal seizures in the term infant.

PMID:
17099361
DOI:
10.1097/MOP.0b013e328010c536
[Indexed for MEDLINE]
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