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Bioinformatics. 2007 Jan 15;23(2):243-4. Epub 2006 Nov 10.

PEAKS: identification of regulatory motifs by their position in DNA sequences.

Author information

1
Research Unit on Biomedical Informatics, Universitat Pompeu Fabra, Barcelona 08003, Spain.

Abstract

Many DNA functional motifs tend to accumulate or cluster at specific gene locations. These locations can be detected, in a group of gene sequences, as high frequency 'peaks' with respect to a reference position, such as the transcription start site (TSS). We have developed a web tool for the identification of regions containing significant motif peaks. We show, by using different yeast gene datasets, that peak regions are strongly enriched in experimentally-validated motifs and contain potentially important novel motifs.

AVAILABILITY:

http://genomics.imim.es/peaks

PMID:
17098773
DOI:
10.1093/bioinformatics/btl568
[Indexed for MEDLINE]

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