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Immunity. 2006 Nov;25(5):695-7.

Human tyk2 kinase deficiency: another primary immunodeficiency syndrome.

Author information

1
Molecular Immunology and Inflammation Branch, National Institutes of Arthritis, Musculoskeletal and Skin Disease, National Institutes of Health, Bethesda, MD 20892, USA.

Abstract

Janus kinases are critical for cytokine signaling. Mutations of Jak3 cause primary immunodeficiency, but Minegishi et al. (2006) now show that mutation of another Jak, tyrosine kinase 2, underlies another human immunodeficiency syndrome.

PMID:
17098200
DOI:
10.1016/j.immuni.2006.10.007
[Indexed for MEDLINE]
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