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Adv Drug Deliv Rev. 2006 Nov 15;58(11):1131-5. Epub 2006 Sep 26.

Challenges and obstacles of ocular pharmacokinetics and drug delivery.

Author information

1
Drug Discovery and Development Technology Center, University of Helsinki, Viikinkaari 5 E, 00014 University of Helsinki, Finland.

Abstract

Modern biological research has produced increasing number of promising therapeutic possibilities for medical treatment. These include for example growth factors, monoclonal antibodies, gene knockdown methods, gene therapy, surgical transplantations and tissue engineering. Ocular application of these possibilities involves drug delivery in many forms. Ocular drug delivery is hampered by the barriers protecting the eye. This review presents an overview of the essential factors in ocular pharmacokinetics and selected pharmacological future challenges in ophthalmology.

PMID:
17097758
DOI:
10.1016/j.addr.2006.07.027
[Indexed for MEDLINE]

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