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Leuk Res. 2007 May;31(5):691-4. Epub 2006 Nov 13.

'Idiopathic' eosinophilia with an Occult T-cell clone: prevalence and clinical course.

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1
Department of Hematology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Abstract

In a study of 99 consecutive patients with "idiopathic" eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (approximately 8%) with an "Occult" T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.

PMID:
17095087
DOI:
10.1016/j.leukres.2006.10.005
[Indexed for MEDLINE]
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