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Fertil Steril. 2007 Feb;87(2):283-7. Epub 2006 Nov 13.

Laser assisted hatching in good prognosis patients undergoing in vitro fertilization-embryo transfer: a randomized controlled trial.

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1
Shady Grove Fertility Reproductive Science Center, Rockville, Maryland 20850, USA.

Abstract

OBJECTIVE:

To evaluate whether assisted hatching improves clinical outcomes of embryo transfers to good prognosis patients, defined as patients < or =39 years with normal follicle-stimulating hormone (FSH) and E(2) levels, no more than one previous unsuccessful cycle of in vitro fertilization (IVF)-embryo transfer, and good embryo quality.

DESIGN:

Prospective randomized controlled trial.

SETTING:

Private assisted reproductive technology (ART) center.

PATIENT(S):

One hundred ninety-nine good prognosis patients undergoing IVF-embryo transfer.

INTERVENTION(S):

In vitro fertilization followed by embryo transfer on day 3 after oocyte retrieval with or without assisted hatching using a 1,480-nm wavelength infrared laser.

MAIN OUTCOME MEASURE(S):

Clinical intrauterine pregnancy, spontaneous pregnancy loss, and live birth.

RESULT(S):

Rates of clinical intrauterine pregnancy with fetal cardiac activity (53% vs. 54% per cycle), spontaneous pregnancy loss (13% vs. 16% per pregnancy), and live birth (47% vs. 46% per cycle) were very similar between treatment cycles with laser-assisted hatching and control cycles in which embryos were transferred without assisted hatching. There were no significant differences between treatment and control groups in any measured clinical outcome parameters.

CONCLUSION(S):

Assisted hatching does not improve clinical outcomes among good prognosis patients.

[Indexed for MEDLINE]

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