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Intensive Care Med. 2007 Feb;33(2):350-4. Epub 2006 Nov 9.

Noninvasive ventilation in patients with "do-not-intubate" orders: medium-term efficacy depends critically on patient selection.

Author information

1
Critical Care Center, Hospital de Sabadell, Parc TaulĂ­ s/n, 08208, Sabadell, Spain. rfernandez@cspt.es

Abstract

OBJECTIVE:

Randomized clinical trials demonstrating benefits of noninvasive ventilation (NIV) systematically exclude patients with "do-not-intubate" (DNI) orders, but in daily clinical practice these patients are frequently treated with NIV. A recent North American study found a 43% hospital survival rate in patients with DNI orders. Our hypothesis was that, due to the very different social and cultural setting, written DNI orders in a southern European country would be restricted to a population with a poor outcome, independently of whether they receive NIV, and we analyzed hospital survival in patients receiving NIV and the impact of DNI orders on survival.

DESIGN AND SETTING:

Retrospective cohort study in a general ICU in a university-affiliated hospital.

PATIENTS AND METHODS:

All 233 patients treated with NIV during 2002-2004. We recorded clinical characteristics on admission, mortality risk by APACHE II and ICU and hospital outcome, and 6-month outcome.

RESULTS:

Hospital survival was 66%. Survival was better in the 199 patients without DNI orders than in the 36 with DNI orders both during hospitalization (74% vs. 26%, OR 7.9) and after 6 months (64% vs. 15%, OR 10.2). In both groups the presence of COPD was associated with better prognosis during hospitalization, but not in the medium-term.

CONCLUSION:

Our study suggests that NIV offers low expectations for medium-term survival in DNI patients.

PMID:
17093982
DOI:
10.1007/s00134-006-0437-6
[Indexed for MEDLINE]

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