Format

Send to

Choose Destination
Drug Resist Updat. 1998;1(5):310-24.

Nucleoside transport and its significance for anticancer drug resistance.

Author information

1
Department of Oncology, University of Alberta, and Cross Cancer Institute, Edmonton, Alberta, Canada.

Abstract

This article discusses the role of nucleoside transport processes in the cytotoxicity of clinically important anticancer nucleosides. This article summarizes recent advances in the molecular biology of nucleoside transport proteins, review the current state of knowledge of the transportability of therapeutically useful anticancer nucleosides, and provide an overview of the role of nucleoside transport deficiency as a mechanism of resistance to nucleoside cytotoxicity are summarized. Several strategies for utilization of nucleoside transport processes to improve the therapeutic index of anticancer therapies, including the use of nucleoside-transport inhibitors to modulate toxicity of both nucleoside and non-nucleoside antimetabolite drugs are also presented.

PMID:
17092812

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center