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Drug Resist Updat. 1998 Mar;1(1):49-58.

Mobile elements in the evolution and spread of multiple-drug resistance in staphylococci.

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School of Biological Sciences, University of Sydney, New South Wales, Australia.


Since the introduction of antimicrobial chemotherapy, staphylococci have shown a remarkable propensity to develop drug resistance. As a result, strains have evolved that are resistant to most classes of clinically useful antimicrobial agents. The emergence of these multiply-drug-resistant strains is primarily due to the capture of pre-existent resistance genes. In combination with plasmids and gene transfer mechanisms, mobile genetic elements have been central to the acquisition and dissemination of this resistance. In particular they have played a significant role in the assembly of drug-resistance gene clusters in these multiply-resistant staphylococci.


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