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FEBS Lett. 2006 Nov 27;580(27):6361-5. Epub 2006 Nov 7.

Intron exclusion and the mystery of intron loss.

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  • 1Pharmacology Department, University of Pittsburgh, W1301, BST, 200 Lothrop Street, PA 15213, USA.


Mechanisms for loss and gain of introns are elusive. Reported here is a new pattern of intron loss which features a random loss of a single intron in a multiple-intron gene with its neighboring introns remained, which process is defined as intron exclusion. Intron exclusion is reminiscent of removal of a limited stretch of non-homologous sequence in a homologous recombination (HR) triggered by a double strand break (DSB), and therefore lends further evidence for a theory of intron loss through HR between a cDNA and its genomic intron-containing locus. Thus, a model for intron loss is formulated.

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