Abstract
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Dose-Response Relationship, Drug
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Doxorubicin / chemistry
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Drug Delivery Systems*
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Ferric Compounds / chemistry
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Humans
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Hydrogen-Ion Concentration
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Integrin alphaVbeta3 / chemistry
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Ligands
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Magnetic Resonance Imaging*
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Micelles
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Nanoparticles / chemistry
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Neoplasms / chemistry*
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Oligopeptides / chemistry*
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Oligopeptides / pharmacology
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Polymers / chemistry*
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Polymers / pharmacology
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Sensitivity and Specificity
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Structure-Activity Relationship
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Surface Properties
Substances
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Ferric Compounds
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Integrin alphaVbeta3
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Ligands
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Micelles
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Oligopeptides
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Polymers
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ferric oxide
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arginyl-glycyl-aspartic acid
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Doxorubicin