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Thorac Cardiovasc Surg. 2006 Oct;54(7):484-8.

Pulmonary metastasectomy following chemotherapy in patients with testicular tumors: experience in 52 patients.

Author information

1
Department of Thoracic Surgery, Thoraxklinik Heidelberg, University of Heidelberg, Heidelberg, Germany. joachim.pfannschmidt@thoraxklinik-heidelberg.de

Abstract

BACKGROUND:

Surgical resection is an important form of treatment for residual post-chemotherapy pulmonary masses in patients with non-seminomatous germ cell tumors. We analyzed the outcome and prognostic factors after surgery.

METHODS:

Between 1996 and 2001, 52 patients underwent pulmonary resection of thoracic masses following cisplatin-based chemotherapy. These patients' records were subsequently reviewed.

RESULTS:

The overall 5-year survival rate was 75.8 %. A significantly longer survival was observed using multivariate analysis in patients with normal serum AFP and/or hCG tumor marker levels and after complete surgical resection. In patients with viable malignant tumor cells in the resected specimen and in patients with only necrosis/fibrosis or teratoma, the 5-year survival rates were 49.6 % and 82.8 %, respectively. This difference was only statistically significant in univariate analysis.

CONCLUSIONS:

We conclude that pulmonary resection in metastatic non-seminomatous germ cell tumors is a safe and effective treatment modality. Incomplete resection and elevated tumor marker levels, AFP and/or hCG, were identified as prognosis-related criteria for a poor outcome in multivariate analysis.

PMID:
17089317
DOI:
10.1055/s-2006-924246
[Indexed for MEDLINE]

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