Format

Send to

Choose Destination
See comment in PubMed Commons below
Antimicrob Agents Chemother. 2007 Feb;51(2):759-62. Epub 2006 Nov 6.

Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.

Author information

1
University of Queensland, Department of Medicine, Brisbane, Australia. tinaS@qimr.edu.au

Abstract

The antimalarial activity of several antiretroviral protease inhibitor combinations was investigated. Data demonstrate that ritonavir and saquinavir behave synergistically with chloroquine and mefloquine. These data, and interactions with pepstatin-A, E-64, and bestatin, suggest that human immunodeficiency virus protease inhibitors do not target digestive-vacuole plasmepsins.

PMID:
17088482
PMCID:
PMC1797772
DOI:
10.1128/AAC.00840-06
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center