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Infect Immun. 2007 Jan;75(1):527-30. Epub 2006 Nov 6.

Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis.

Author information

1
Division of Infectious Diseases, Department of Medicine,Vanderbilt University School of Medicine, 1161 21st Avenue, AA2200 MCN, Nashville, TN 37232, USA. Wonder.drake@vanderbilt.edu

Abstract

Sarcoidosis is an enigmatic disease with a pathology similar to that of tuberculosis. We detected Th-1 immune responses to Mycobacterium tuberculosis ESAT-6 and KatG peptides from peripheral blood mononuclear cells from 15/26 sarcoidosis, 1/24 purified-protein-derivative-negative (PPD-) (P < 0.0001, Fisher's exact test), and 7/8 PPD-positive (PPD+) subjects (P = 0.21). This finding provides immunologic links between mycobacteria and systemic sarcoidosis.

PMID:
17088357
PMCID:
PMC1828402
DOI:
10.1128/IAI.00732-06
[Indexed for MEDLINE]
Free PMC Article

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