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Neuron. 2006 Nov 9;52(3):403-7.

Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

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1
Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, San Francisco, California 94143, USA. tzingoun@cmpmail.ucsf.edu

Abstract

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.

PMID:
17088207
DOI:
10.1016/j.neuron.2006.10.016
[Indexed for MEDLINE]
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