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J Allergy Clin Immunol. 2006 Nov;118(5):1054-9. Epub 2006 Sep 18.

Eosinophilic esophagitis: pathogenesis, genetics, and therapy.

Author information

1
Division of Allergy, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

Abstract

Eosinophilic esophagitis (EE) is a recently recognized disorder characterized by the accumulation of eosinophils in the esophagus. Symptoms of EE frequently mimic those of gastroesophageal reflux disease, but the 2 diseases are quite distinct in terms of the histopathology and response to therapy. We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention.

PMID:
17088129
DOI:
10.1016/j.jaci.2006.07.038
[Indexed for MEDLINE]

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