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Mol Biol (Mosk). 2006 Sep-Oct;40(5):910-8.

[A search for amyloidogenic regions in protein chain].

[Article in Russian]


We suggest a new method to detect amyloidogenic regions in a protein sequence. In the present work it is shown that regions enriched with amino acid residues which have a high expected packing density are responsible for the amyloid formation. Our predictions are consistent with known disease-related amyloidogenic regions for 8 of 11 amyloid-forming proteins and peptides in which positions of amyloidogenic regions have been revealed experimentally.

[Indexed for MEDLINE]

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