Format

Send to

Choose Destination
IUBMB Life. 2006 Nov;58(11):659-63.

Sequestration shapes the response of signal transduction cascades.

Author information

1
Molecular Neurobiology, Free University Berlin, and Institute for Theoretical Biology, Humboldt University Berlin, Berlin, Germany. nils@itb.biologie.hu-berlin.de

Abstract

Many signal transduction cascades are composed of covalent modification cycles such as kinase/phosphatase cycles. In the 1980s Goldbeter and Koshland showed that such cycles can exhibit non-linear input-output relations when the enzymes are saturated by their substrates, which may facilitate signal processing. Recent papers show that this mechanism is unlikely to cause non-linearity in mammalian signal transduction cascades as sequestration of the target due to enzyme concentrations present in these cascades will hamper this mechanism. However, sequestration due to high-affinity enzymes can shape the dynamics and steady-state behaviour of signal transduction cascades in different ways, some of which are discussed in this review.

PMID:
17085386
DOI:
10.1080/15216540600994340
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center