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Cell Metab. 2006 Nov;4(5):341-8.

Convergence between bone and energy homeostases: leptin regulation of bone mass.

Author information

1
Department of Genetics and Development, Columbia University, New York, New York 10032, USA. gk2172@columbia.edu

Abstract

The observation that obesity protects from osteoporosis suggested that energy metabolism and bone mass could be regulated by the same hormones. Testing this hypothesis revealed that leptin regulates bone mass through a hypothalamic relay and using two neural mediators, the sympathetic tone and CART, both acting on one cell type the osteoblast. This review summarizes the genetic and molecular bases of this regulation and discusses its potential clinical implications.

PMID:
17084709
DOI:
10.1016/j.cmet.2006.10.008
[Indexed for MEDLINE]
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