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Curr Opin Neurobiol. 2006 Dec;16(6):723-7. Epub 2006 Nov 3.

Prefrontal involvement in the regulation of emotion: convergence of rat and human studies.

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Department of Physiology, Ponce School of Medicine, P.O. Box 7004, Ponce, Puerto Rico 00732.


Emotion regulation is a process by which we control when and where emotions are expressed. Paradigms used to study the regulation of emotion in humans examine controlled responses to emotional stimuli and/or the inhibition of emotional influences on subsequent behavior. These processes of regulation of emotion trigger activation of the ventromedial prefrontal cortex and inhibition of the amygdala. A similar pattern of activation is seen in rodents during recall of fear extinction, an example of emotional regulation. The overlap in circuitry is consistent with a common mechanism, and points toward future experiments designed to bridge human and rodent models of emotion regulation.

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