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Curr Opin Neurobiol. 2006 Dec;16(6):701-9. Epub 2006 Nov 3.

Representing episodes in the mammalian brain.

Author information

1
Dr. Arthur M. Fishberg Department of Neuroscience, Alfred B. and Gudrun J. Kastor Neurobiology of Aging Laboratories, Mount Sinai School of Medicine, 1 Gustave L Levy Place, New York, NY 10029-6574C, USA. matthew.shapiro@mssm.edu

Erratum in

  • Curr Opin Neurobiol. 2007 Jun;17(3):394.

Abstract

Memory lets the past inform the present so that we can attain future goals. In many species, these abilities require the hippocampus. Recent experiments, in which memory demand was varied while overt behavior and the environment were kept constant, have revealed firing patterns of hippocampal neurons that corresponded with memory demands and predicted performance. Although the active population appeared to be 'place cells' that signalled location, it actually included cells the activity patterns of which distinguished the recent or pending history of behavior during identical actions that occurred in the same place. Different populations of hippocampal cells fired as a rat walked along the same spatial path on the way to different goals, and coded past, present and pending events. Other experiments provide converging data that neuronal activity is modulated by goal-directed behavioral episodes. Together, these firing patterns suggest a testable mechanism of episodic memory coding: that hippocampal dynamics encode a temporally extended, hierarchically organized representation of goal-directed behavior.

PMID:
17084616
DOI:
10.1016/j.conb.2006.08.017
[Indexed for MEDLINE]

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