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Int J Radiat Oncol Biol Phys. 2007 Jan 1;67(1):164-70. Epub 2006 Nov 2.

Intensity modulated radiation-therapy for preoperative posterior abdominal wall irradiation of retroperitoneal liposarcomas.

Author information

  • 1Department of Radiation Oncology, University Hospitals Gasthuisberg, Leuven, Belgium. alberto.bossi@uz.kuleuven.ac.be

Erratum in

  • Int J Radiat Oncol Biol Phys. 2007 May 1;68(1):317. Dosage error in article text.

Abstract

PURPOSE:

Preoperative external-beam radiation therapy (preop RT) in the management of Retroperitoneal Liposarcomas (RPLS) typically involves the delivery of radiation to the entire tumor mass: yet this may not be necessary. The purpose of this study is to evaluate a new strategy of preop RT for RPLS in which the target volume is limited to the contact area between the tumoral mass and the posterior abdominal wall.

METHODS AND MATERIALS:

Between June 2000 and Jan 2005, 18 patients with the diagnosis of RPLS have been treated following a pilot protocol of pre-op RT, 50 Gy in 25 fractions of 2 Gy/day. The Clinical Target Volume (CTV) has been limited to the posterior abdominal wall, region at higher risk for local relapse. A Three-Dimensional conformal (3D-CRT) and an Intensity Modulated (IMRT) plan were generated and compared; toxicity was reported following the National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events v3.0.

RESULTS:

All patients completed the planned treatment and the acute toxicity was tolerable: 2 patients experienced Grade 3 and 1 Grade 2 anorexia while 2 patients developed Grade 2 nausea. IMRT allows a better sparing of the ipsilateral and the contralateral kidney. All tumors were successfully resected without major complications. At a median follow-up of 27 months 2 patients developed a local relapse and 1 lung metastasis.

CONCLUSIONS:

Our strategy of preop RT is feasible and well tolerated: the rate of resectability is not compromised by limiting the preop CTV to the posterior abdominal wall and a better critical-structures sparing is obtained with IMRT.

PMID:
17084556
DOI:
10.1016/j.ijrobp.2006.08.023
[PubMed - indexed for MEDLINE]
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