Format

Send to

Choose Destination
See comment in PubMed Commons below
Toxicon. 2007 Jan;49(1):106-10. Epub 2006 Oct 18.

Microvesicles in the venom of Crotalus durissus terrificus (Serpentes, Viperidae).

Author information

  • 1Laboratório de Biologia Celular, Instituto Butantan, Av. Vital Brasil, 1500, São Paulo, SP 05503-900, Brasil. sycarneiro@butantan.gov.br

Abstract

Microvesicles with electron-dense content are consistently observed by transmission electron microscopy on the luminal face of secretory cells of venom glands of viperid snakes. In this work, we evaluated their presence in Crotalus durissus terrificus venom glands and also in freshly collected venom. Microvesicles were found in the venom glands mainly in regions of exocytosis. They ranged from 40 to 80 nm in diameter. Freeze-fracture replicas of the glands revealed particles on the cytoplasmic leaflet (P-face) of these vesicles, suggesting that they carry transmembrane proteins. Vesicles separated by ultracentrifugation from cell-free venom were similar in size and structure to the microvesicles observed in the glands. A fine fuzzy coat surrounded each microvesicle. The function of these venom vesicles is still unknown, but they may contribute to inactivation of stored venom components, or their activation after the venom is released.

PMID:
17084429
DOI:
10.1016/j.toxicon.2006.04.020
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center