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Trends Parasitol. 2007 Jan;23(1):1-3. Epub 2006 Nov 2.

Toll road for Toxoplasma gondii: the mystery continues.

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Department of Microbiology, Immunology and Tropical Medicine, George Washington University Medical Center, Ross Hall Suite 736, 2300 Eye Street NW, Washington, DC 20037, USA.


Toll-like receptors (TLRs) are considered to be essential for the initiation of immune responses against pathogens. Although myeloid differentiation factor 88 an adaptor molecule for most TLRs, is important for protection against Toxoplasma gondii, the TLR responsible for eliciting an immune response against this obligate intracellular pathogen remains unknown. A recent article reports that mice lacking TLR9 cannot develop severe inflammatory responses to T. gondii infection. The implications of this finding are discussed here.

[Indexed for MEDLINE]

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