Format

Send to

Choose Destination
J Infect Dis. 2006 Dec 1;194(11):1597-600. Epub 2006 Oct 18.

Rapid systemic bone resorption during the course of Staphylococcus aureus-induced arthritis.

Author information

1
Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, S-41346 Goteborg, Sweden. margareta.verdrengh@rheuma.gu.se

Abstract

Bacterial arthritis is the most rapidly progressing destructive joint disease in humans. To evaluate bone resorption and formation, mice were injected with Staphylococcus aureus and killed after 3 and 14 days. Both total and trabecular bone mineral density were, compared with those in uninfected controls, already significantly reduced 3 days after bacterial inoculation. Serum levels of type I collagen fragments were significantly increased and osteocalcin levels decreased in mice infected with S. aureus, compared with those in noninfected mice, 3 and 14 days after bacterial inoculation. This study shows that there is a rapid and easily measurable systemic bone resorption during S. aureus-induced arthritis.

PMID:
17083046
DOI:
10.1086/508751
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center