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J Infect Dis. 2006 Dec 1;194(11):1597-600. Epub 2006 Oct 18.

Rapid systemic bone resorption during the course of Staphylococcus aureus-induced arthritis.

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Department of Rheumatology and Inflammation Research, Sahlgrenska Academy, S-41346 Goteborg, Sweden.


Bacterial arthritis is the most rapidly progressing destructive joint disease in humans. To evaluate bone resorption and formation, mice were injected with Staphylococcus aureus and killed after 3 and 14 days. Both total and trabecular bone mineral density were, compared with those in uninfected controls, already significantly reduced 3 days after bacterial inoculation. Serum levels of type I collagen fragments were significantly increased and osteocalcin levels decreased in mice infected with S. aureus, compared with those in noninfected mice, 3 and 14 days after bacterial inoculation. This study shows that there is a rapid and easily measurable systemic bone resorption during S. aureus-induced arthritis.

[Indexed for MEDLINE]

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