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Psychopharmacology (Berl). 2007 Jan;189(4):531-7. Epub 2006 Nov 3.

MDMA use and neurocognition: a meta-analytic review.

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  • 1Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA. adk@ucla.edu

Abstract

RATIONALE:

To determine the association between MDMA misuse and neurocognition using meta-analysis.

OBJECTIVE:

Separate analyses were conducted based on two sets of inclusion/exclusion criteria. A relatively stringent set required that the subjects be matched on important moderator variables, whereas the other did not. The study participants' performance in the following neurocognitive domains was reviewed: attention/concentration, verbal and nonverbal learning and memory, psychomotor speed and executive systems functioning.

RESULTS:

In the 11 studies meeting the relatively stringent inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Similarly, in the 23 studies meeting the relatively lenient inclusion/exclusion criteria for this review, MDMA use was associated with neurocognitive deficits in each domain. Small to medium effect sizes were generally observed. A comparison of the effect sizes across the two sets of analyses did not reveal significant differences.

CONCLUSIONS:

The findings from this review reveal that MDMA use is associated with neurocognitive deficits. The implications of these findings are discussed.

[PubMed - indexed for MEDLINE]
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