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Cell. 2006 Nov 3;127(3):465-8.

PGC-1alpha, a new therapeutic target in Huntington's disease?

Author information

1
Department of Neurology, Cornell Medical Center, New York, NY 10021, USA.

Abstract

The coactivator PGC-1alpha is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1alpha expression is downregulated in patients with Huntington's disease (HD) and in several animal models of this neurodegenerative disorder, implicating PGC-1alpha in HD pathogenesis and providing a connection between impaired energy metabolism and neurodegeneration.

PMID:
17081970
DOI:
10.1016/j.cell.2006.10.023
[Indexed for MEDLINE]
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