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Immunity. 2006 Nov;25(5):757-68. Epub 2006 Nov 2.

Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB.

Author information

1
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

LAB (linker for activation of B cells), also known as NTAL (non-T cell activation linker), is a LAT (linker for activation of T cells)-like adaptor protein that is expressed in B, NK, and mast cells. Its role in lymphocytes has not been clearly demonstrated. Here, we showed that aged LAB-deficient (Lat2(-/-)) mice developed an autoimmune syndrome. Lat2(-/-) T cells were hyperactivated and produced more cytokines than Lat2(+/+) T cells. Even though LAB was absent in naive T cells, LAB could be detected in activated Lat2(+/+) T cells. LAT-mediated signaling events were enhanced in Lat2(-/-) T cells; however, they were suppressed in T cells that overexpressed LAB. Mice with the Lat2 gene conditionally deleted from T cells also developed the autoimmune syndrome like Lat2(-/-) mice. Together, these data demonstrated an important role of LAB in limiting autoimmune response and exposed a mechanism regulating T cell activation.

PMID:
17081783
DOI:
10.1016/j.immuni.2006.08.025
[Indexed for MEDLINE]
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