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Fertil Steril. 2007 Jan;87(1):213-6. Epub 2006 Nov 1.

Effect of reduced oxygen concentrations on the outcome of in vitro fertilization.

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School of Medicine, Stanford University, Stanford, California 94305, USA.


We compared the effects of two standard oxygen concentrations, physiological (5% O(2), 5% CO(2), and 90% N(2)) and atmospheric (5% CO(2) with the balance as air), on fertilization, embryo development, and pregnancy rate in 106 patients undergoing IVF, excluding donor oocyte cycles and preimplantation genetic diagnosis cycles. The differences in oxygen concentration did not significantly affect fertilization rate, blastocyst formation, or pregnancy rate, but there was a significant difference in mean embryo score between physiological and atmospheric groups on day 3.

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