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J Pharm Pharmacol. 1990 Nov;42(11):773-7.

Anti-allergic effect of N-acetylneuraminic acid in guinea-pigs.

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Department of Pharmacological Sciences, Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.


The in-vivo anti-allergic effect of N-acetylneuraminic acid (NANA) in guinea-pigs passively sensitized with anti-ovalbumin rabbit serum has been studied. NANA (20 mg kg-1 i.v.) inhibited bronchial anaphylaxis and the release of histamine into bronchoalveolar lavage fluid. NANA dose-dependently inhibited heterologous passive cutaneous anaphylaxis and haemorrhaging in the passive Arthus reaction. However, it did not inhibit the release of histamine from sensitized minced lung tissue.

[Indexed for MEDLINE]

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