ATP-producing and consuming processes of Ehrlich mouse ascites tumor cells in proliferating and resting phases

H Schmidt; W Siems; M Müller; R Dumdey; S M Rapoport

doi:10.1016/0014-4827(91)90140-p

ATP-producing and consuming processes of Ehrlich mouse ascites tumor cells in proliferating and resting phases

Exp Cell Res. 1991 May;194(1):122-7. doi: 10.1016/0014-4827(91)90140-p.

Authors

H Schmidt¹, W Siems, M Müller, R Dumdey, S M Rapoport

Affiliation

¹ Department of Pediatrics, Humboldt University (Charité), Berlin, Federal Republic of Germany.

PMID: 1707821
DOI: 10.1016/0014-4827(91)90140-p

Abstract

The extents of ATP-yielding and consuming processes in Ehrlich mouse ascites tumor cells during the proliferating and resting growth phase were compared. In the resting phase the total ATP production was decreased by one-third. The ATP supply by oxidative phosphorylation was drastically reduced, whereas the rate of glycolysis stayed nearly constant. All ATP-consuming processes investigated, i.e., protein turnover, Na+/K(+)-ATPase, Ca2(+)-ATPase, and RNA synthesis, were decreased proportionally with the total ATP consumption.

MeSH terms

Adenosine Triphosphate / metabolism*
Animals
Calcium-Transporting ATPases / metabolism
Carcinoma, Ehrlich Tumor / metabolism
Carcinoma, Ehrlich Tumor / pathology*
Carcinoma, Ehrlich Tumor / physiopathology
Cell Division / physiology
Cell Transformation, Neoplastic / metabolism
Cell Transformation, Neoplastic / pathology*
Female
Glycolysis / physiology
Mice
Mice, Inbred ICR
Neoplasm Proteins / metabolism
Oxidative Phosphorylation
RNA / biosynthesis
Sodium-Potassium-Exchanging ATPase / metabolism

Substances

Neoplasm Proteins
RNA
Adenosine Triphosphate
Calcium-Transporting ATPases
Sodium-Potassium-Exchanging ATPase