Format

Send to

Choose Destination
See comment in PubMed Commons below
J Clin Endocrinol Metab. 2007 Feb;92(2):497-503. Epub 2006 Oct 31.

Smoking is associated with lower bone mineral density and reduced cortical thickness in young men.

Author information

1
Cente for Bone Resarch at the Sahlgrenska Academy, Gothenburg, Sweden. mattias.lorentzon@medic.gu.se

Abstract

CONTEXT:

Smoking has previously been associated with reduced areal bone mineral density (aBMD) in elderly subjects, but the association remains controversial in adolescents.

OBJECTIVE:

The aim of this study was to determine whether smoking was associated with aBMD or volumetric BMD (vBMD) and bone size in young men.

DESIGN AND SETTING:

aBMD was measured using dual x-ray absorptiometry. vBMD and bone size were measured using peripheral quantitative computerized tomography (pQCT). Smoking habits were assessed using questionnaires. Levels of sex steroids, PTH, and 25-OH-vitamin D were measured in serum.

PARTICIPANTS:

The population-based Gothenburg Osteoporosis and Obesity Determinants (GOOD) study includes 1068 young men, age 18.9 +/- 0.6 yr (mean +/- SD).

MAIN OUTCOME MEASURE:

The main outcome measure was smoking as predictor of bone parameters and serum sex hormone levels.

RESULTS:

Of the study subjects, 8.7% smoked daily. Bone parameters were compared between smokers and nonsmokers. Smokers had significantly lower aBMD (dual x-ray absorptiometry) of the total body (crude: -2.1%; adjusted for age, height, weight, calcium intake, and physical activity: -1.8%), lumbar spine (crude: -4.3%; adjusted: -3.3%), and trochanter (crude: -6.6%; adjusted: -5.0%) than nonsmokers. Using peripheral quantitative computerized tomography, we found that smokers had lower cortical thickness of both the radius (crude: -2.8%; adjusted: -2.9%) and tibia (crude: -4.5%; adjusted: -4.0%) than the nonsmokers, whereas no difference was seen for cortical vBMD. Smokers had higher serum levels of total and free testosterone and lower 25-OH-vitamin D than nonsmokers. Adjustment for testosterone and/or 25-OH-vitamin D levels did not alter the associations between smoking and bone parameters.

CONCLUSIONS:

We demonstrate that smoking was associated with lower aBMD and reduced cortical thickness in young men.

Comment in

PMID:
17077132
DOI:
10.1210/jc.2006-1294
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center