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Int J Obes (Lond). 2007 May;31(5):743-50. Epub 2006 Oct 31.

Changes in fat-free mass during significant weight loss: a systematic review.

Author information

1
Australian Centre for Obesity Research and Education, Monash University, Monash Medical School, The Alfred Hospital, Melbourne, Victoria, Australia.

Abstract

OBJECTIVE:

To identify the proportion of weight lost as fat-free mass (FFM) by various weight loss interventions.

METHODS:

Medline and Embase were systematically searched for reliable measurements of FFM before and after weight loss of >10 kg and eligible data were pooled. In a fixed effect model of % FFM loss/weight loss (%FFML), linear regression analysis was used to determine the influence of degree of caloric restriction, exercise, magnitude of weight loss, initial body mass index (BMI) and type of surgery.

RESULTS:

Data were included from 26 cohorts treated with dietary and behavioral interventions and 29 cohorts of bariatric surgery patients. The degree of caloric restriction was positively associated with %FFML (r (2)=0.31, P=0.006) and in three randomized controlled trials exercise was shown to decrease %FFML. Compared with laparoscopic adjustable gastric banding (LAGB), biliopancreatic diversion (BPD) and roux en Y gastric bypass (RYGB) caused greater log(e) (natural log) %FFML (r (2)=0.453, P<0.001). Differences in log(e) %FFML between surgical procedures were independent of initial BMI and magnitude of weight loss.

CONCLUSIONS:

The degree of caloric restriction, exercise and rate of weight loss influence the proportion of weight lost as FFM after non-surgical interventions. For surgical interventions, BPD and RYGB result in greater %FFML than LAGB.

PMID:
17075583
DOI:
10.1038/sj.ijo.0803483
[Indexed for MEDLINE]
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