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Pharmacol Ther. 1990;48(3):381-95.

Metabolism and mechanism of action of 5-fluorouracil.

Author information

1
Kettering-Meyer Laboratory, Southern Research Institute, Birmingham, AL 35205.

Abstract

This is a review on the mechanism of action of FUra. Three main areas are addressed: metabolism, RNA-directed actions of FUra, and DNA-directed actions of FUra. Key words for bibliographic purposes: metabolism, RNA, rRNA, mRNA, tRNA, DNA primase, DNA, thymidylate synthetase, uracil N-glycosylase, FUra, FUrd, FdUrd, FdUMP, RNA splicing, 5,10-methylene tetrahydrofolate, FUTP.

PMID:
1707544
DOI:
10.1016/0163-7258(90)90056-8
[Indexed for MEDLINE]

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