Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae

Hyunjoo Pai; Mi-Ran Seo; Tae Yeal Choi

doi:10.1128/AAC.00841-06

Association of QnrB determinants and production of extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases in clinical isolates of Klebsiella pneumoniae

Antimicrob Agents Chemother. 2007 Jan;51(1):366-8. doi: 10.1128/AAC.00841-06. Epub 2006 Oct 30.

Authors

Hyunjoo Pai¹, Mi-Ran Seo, Tae Yeal Choi

Affiliation

¹ Division of Infectious Diseases, College of Medicine, Hanyang University, Seoul 133-791, Korea. paihj@hanyang.ac.kr

Abstract

Clinical isolates of Escherichia coli and Klebsiella pneumoniae producing extended-spectrum beta-lactamases or plasmid-mediated AmpC beta-lactamases were screened for qnrA and qnrB genes. QnrB was present in 54 of 54 DHA-1-producing K. pneumoniae isolates and 10 of 45 SHV-12-producing ones, suggesting that the distribution of plasmids conferring resistance to extended-spectrum cephalosporins and quinolones in clinical isolates of K. pneumoniae is widespread.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Bacterial Proteins / genetics*
Cephalosporins / pharmacology
Drug Resistance, Multiple, Bacterial / genetics
Escherichia coli / drug effects
Escherichia coli / genetics
Humans
Klebsiella Infections / microbiology
Klebsiella pneumoniae / drug effects
Klebsiella pneumoniae / enzymology
Klebsiella pneumoniae / genetics*
Microbial Sensitivity Tests
Plasmids / genetics*
Quinolones / pharmacology
beta-Lactam Resistance / genetics
beta-Lactamases / genetics*

Substances

Anti-Bacterial Agents
Bacterial Proteins
Cephalosporins
Quinolones
AmpC beta-lactamases
beta-Lactamases