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Trends Biochem Sci. 2006 Dec;31(12):647-53. Epub 2006 Oct 30.

ATP-dependent proteases of bacteria: recognition logic and operating principles.

Author information

1
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. tabaker@mit.edu

Abstract

ATP-powered AAA+ proteases degrade specific proteins in intracellular environments occupied by thousands of different proteins. These proteases operate as powerful molecular machines that unfold stable native proteins before degradation. Understanding how these enzymes choose the "right" protein substrates at the "right" time is key to understanding their biological function. Recently, proteomic approaches have identified numerous substrates for some bacterial enzymes and the sequence motifs responsible for recognition. Advances have also been made in elucidating the mechanism and impact of adaptor proteins in regulating substrate choice. Finally, recent biochemical dissection of the ATPase cycle and its coupling to protein unfolding has revealed fundamental operating principles of this important, ubiquitous family of molecular machines.

PMID:
17074491
PMCID:
PMC2717004
DOI:
10.1016/j.tibs.2006.10.006
[Indexed for MEDLINE]
Free PMC Article

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