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Fertil Steril. 2007 Mar;87(3):603-6. Epub 2006 Oct 30.

Exclusion of coding-region mutations in luteinizing hormone and follicle-stimulating hormone receptor genes as the cause of ovarian hyperstimulation syndrome.

Author information

1
Department of Biosciences, Novum, Karolinska Institutet, Huddinge, Sweden.

Abstract

OBJECTIVE:

To sequence the coding regions of the luteinizing hormone receptor (LHR) and follicle-stimulating hormone receptor (FSHR) genes to find out if polymorphisms in them are responsible for the severe form of ovarian hyperstimulation syndrome (OHSS) in Swedish patients.

DESIGN:

A mutation analysis of gonadotropin receptor genes from women undergoing gonadotropin treatment.

SETTING:

The Fertility Unit of Karolinska University Hospital Huddinge, Stockholm, Sweden.

PATIENT(S):

A set of 10 well-characterized patients with severe OHSS, and 10 control women who did not develop OHSS after FSH stimulation. An additional 11 patients and 41 control women were screened for a two-amino-acid insertion in the first exon of the LHR gene.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Changes in the sequence of the receptor genes between patients and controls.

RESULT(S):

No association was found between polymorphisms of the coding region of LHR or FSHR genes and the development of OHSS. Incidence of the two-amino-acid insertion in the first exon of the LHR gene was slightly higher in patients than in controls, but no statistically significant difference was seen.

CONCLUSION:

LHR and FSHR coding polymorphisms are not a major cause of severe OHSS in Swedish patients.

[Indexed for MEDLINE]

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