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Biochem Soc Trans. 2006 Dec;34(Pt 6):1014-7.

The chemoattractant decoy receptor D6 as a negative regulator of inflammatory responses.

Author information

1
Istituto Clinico Humanitas, Via Manzoni 56, I-20089 Rozzano, Milan, Italy.

Abstract

Other than signalling receptors sustaining leucocyte recruitment during inflammatory reactions, the chemokine system includes 'silent' receptors with distinct specificity and tissue distribution. The best-characterized molecule of this subgroup is the CC chemokine receptor D6, which binds most inflammatory CC chemokines and targets them to degradation via constitutive ligand-independent internalization. Structure-function analysis and recent results with gene-targeted animals indicate that D6 has unique functional and structural features, which make it ideally adapted to act as a chemokine decoy and scavenger receptor, strategically located on lymphatic endothelium and placenta to dampen inflammation in tissues and draining lymph nodes.

PMID:
17073740
DOI:
10.1042/BST0341014
[Indexed for MEDLINE]

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