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Curr Drug Targets. 2006 Oct;7(10):1329-34.

Targeting the oncogenic tyrosine kinase NPM-ALK in lymphoma: the role of murine models in defining pathogenesis and treatment options.

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Department of Internal Medicine III, Klinikum rechts der Isar, Technical University of Munich, Trogerstr. 32, D-81675 Munich, Germany.


Oncogenic tyrosine kinases play a ever growing role in the pathogenesis of human malignancies. In human non-Hodgkin lymphomas, the NPM-ALK oncogene arising from the t(2;5) chromosomal translocation represents the most important oncogenic tyrosine kinase identified so far. The ALK-kinase is constitutively activated by NPM-induced dimerization and signals through a multitude of growth promoting and antiapoptotic pathways. Murine models have made a significant impact on the elucidation of the molecular pathogenesis and new treatment options of malignant diseases. Here, the latest developments in the analysis of NPM-ALK induced lymphomagenesis by murine models is reviewed.

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