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Emerg Infect Dis. 2006 Sep;12(9):1389-97.

Multidrug-resistant tuberculosis management in resource-limited settings.

Author information

1
Stop TB Department, World Health Organization, Geneva, Switzerland. nathansone@who.int

Abstract

Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: Estonia, Latvia, Peru, the Philippines, and the Russian Federation. All projects were approved by the Green Light Committee for access to quality-assured second-line drugs provided at reduced price for MDRTB management. Of 1047 MDRTB patients evaluated, 119 (11%) were new, and 928 (89%) had received treatment previously. More than 50% of previously treated patients had received both first- and second-line drugs, and 65% of all patients had infections that were resistant to both first- and second-line drugs. Treatment was successful in 70% of all patients, but success rate was higher among new (77%) than among previously treated patients (69%). In resource-limited settings, treatment of MDRTB provided through, or in collaboration with, national TB programs can yield results similar to those from wealthier settings.

PMID:
17073088
PMCID:
PMC3294733
DOI:
10.3201/eid1209.051618
[Indexed for MEDLINE]
Free PMC Article

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