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Yeast. 2006 Oct 15;23(13):913-9.

Gene Ontology annotation status of the fission yeast genome: preliminary coverage approaches 100%.

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  • 1Wellcome Trust Sanger Institute, Cambridge CB10 1HH, UK.

Erratum in

  • Yeast. 2007 May;24(5):457.


In this review, we present an overview of the Gene Ontology (GO) structure and describe how the GO is implemented for Sz. pombe and made available via Sz. pombe GeneDB ( We give a detailed progress report of Sz. pombe GO annotation, providing the current status of both manual and automatic annotations. Fission yeast has at least one GO annotation for 98.3% of its genes (excluding annotations to 'unknown' terms), greater than the current percentage coverage for any other organism. Approximately 65% (3225 gene products) have at least one annotation to each of the three ontologies (biological process, cellular component and molecular function). Approximately 30% (1443 gene products) have GO terms derived directly from small-scale experiments in fission yeast, supporting the validity of fission yeast as a model eukaryote and a reference organism.

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