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Oncogene. 2006 Oct 30;25(51):6758-80.

NF-kappaB and the immune response.

Author information

1
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

One of the primary physiological roles of nuclear factor-kappa B (NF-kappaB) is in the immune system. In particular, NF-kappaB family members control the transcription of cytokines and antimicrobial effectors as well as genes that regulate cellular differentiation, survival and proliferation, thereby regulating various aspects of innate and adaptive immune responses. In addition, NF-kappaB also contributes to the development and survival of the cells and tissues that carry out immune responses in mammals. This review, therefore, describes the role of the NF-kappaB pathway in the development and functioning of the immune system.

PMID:
17072327
DOI:
10.1038/sj.onc.1209943
[Indexed for MEDLINE]

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