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Science. 1991 Mar 29;251(5001):1605-8.

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis.

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Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.


Derivatives of the sunY self-splicing intron efficiently catalyzed the synthesis of complementary strand RNA by template-directed assembly of oligonucleotides. These ribozymes were separated into three short RNA fragments that formed active catalytic complexes. One of the multisubunit sunY derivatives catalyzed the synthesis of a strand of RNA complementary to one of its own subunits. These results suggest that prebiotically synthesized oligonucleotides might have been able to assemble into a complex capable of self-replication.

[Indexed for MEDLINE]

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