Format

Send to

Choose Destination
Science. 1991 Mar 29;251(5001):1605-8.

A multisubunit ribozyme that is a catalyst of and template for complementary strand RNA synthesis.

Author information

1
Department of Molecular Biology, Massachusetts General Hospital, Boston 02114.

Abstract

Derivatives of the sunY self-splicing intron efficiently catalyzed the synthesis of complementary strand RNA by template-directed assembly of oligonucleotides. These ribozymes were separated into three short RNA fragments that formed active catalytic complexes. One of the multisubunit sunY derivatives catalyzed the synthesis of a strand of RNA complementary to one of its own subunits. These results suggest that prebiotically synthesized oligonucleotides might have been able to assemble into a complex capable of self-replication.

PMID:
1707185
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center