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Bioorg Med Chem Lett. 2007 Jan 15;17(2):527-32. Epub 2006 Oct 7.

Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.

Author information

1
Abbott, Dept. 47F, Bldg. AP-10, Rm. 301, 100 Abbott Park Road, Abbott Park, IL 60064-6098, USA.

Abstract

Potent and selective adamantane sulfone and sulfonamide inhibitors of 11-beta-HSD-1 have been discovered. Selected compounds from these series have robust pharmacokinetic profiles and strongly inhibit liver, fat, and brain HSD1 for extended periods after oral dosing.

PMID:
17070044
DOI:
10.1016/j.bmcl.2006.10.008
[Indexed for MEDLINE]

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