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Semin Cell Dev Biol. 2006 Oct;17(5):565-70. Epub 2006 Sep 24.

alpha2delta and the mechanism of action of gabapentin in the treatment of pain.

Author information

1
Cambridge Biotechnology Ltd., Biovitrum AB, Babraham Research Campus, Cambridge CB2 4AT, UK.

Abstract

Gabapentin is a drug that has been widely used in the treatment of chronic pain states. Despite its widespread usage, it is only recently that light has been shed on the mechanism of action of this agent. In the current review, the authors document the pharmacological, biochemical and molecular information that has led to the identification of the alpha2delta1 auxilliary subunit of voltage gated calcium channels as the target for this drug's actions.

PMID:
17067834
DOI:
10.1016/j.semcdb.2006.09.003
[Indexed for MEDLINE]
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