[Cutaneous necrosis due to interferon alpha in a patient with melanoma]

Actas Dermosifiliogr. 2006 Oct;97(8):539-42. doi: 10.1016/s0001-7310(06)73460-3.
[Article in Spanish]

Abstract

We present the case of a 55-year-old male with melanoma in the right retroauricular region who had cutaneous necrosis only in one of the injection sites after adjuvant treatment with interferon (IFN alpha 2b) according to the Kirkwood proposed regime. Appearance of cutaneous necrosis is a rare condition that has been described in patients treated with different types of IFN.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Anti-Bacterial Agents / therapeutic use
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / adverse effects*
  • Arm
  • Chemotherapy, Adjuvant
  • Debridement
  • Follow-Up Studies
  • Humans
  • Injections, Intravenous
  • Interferon alpha-2
  • Interferon-alpha / administration & dosage
  • Interferon-alpha / adverse effects*
  • Male
  • Melanoma / drug therapy*
  • Melanoma / pathology
  • Melanoma / surgery
  • Middle Aged
  • Necrosis / chemically induced*
  • Necrosis / pathology
  • Ointments
  • Recombinant Proteins
  • Skin / pathology*
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery
  • Skin Ulcer / chemically induced
  • Skin Ulcer / drug therapy
  • Skin Ulcer / surgery
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • Antineoplastic Agents
  • Interferon alpha-2
  • Interferon-alpha
  • Ointments
  • Recombinant Proteins